From the Departments of Cardiovascular Pharmacology (J.T.P., H.L., T.M.A.B.), Pharmacokinetics and Drug Metabolism (H.H.), Biochemistry (L.J.), and Chemistry (P.M.O., D.R.S.), Pfizer Global Research and Development, Ann Arbor, Mich; and Cardiothoracic Surgery, Medical University of South Carolina, Charleston (M.L.C., T.E., F.G.S.).(2001-05-08時点)