Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, and Shandong Key Laboratory of Oral Tissue Regeneration, and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, and Shenzhen Research Institute of Shandong University, Jinan, Shandong, People’s Republic of China (At 2020-07-24)