Departments of Medicinal Chemistry Research 1, 4, and 5 and Drug Metabolism, Health Care Discovery, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark, Departments of Protein Structure, Protein Design, and Signal Transduction, Novo Nordisk A/S, Novo Allé, DK-2880 Bagsværd, Denmark, and Ontogen Corporation, 2325 Camino Vida Roble, Carlsbad, California 92009 (At 2002-08-24)