From the Departments of Medicine (S.K., T.Y., M.E.A., M.A.M., D.M.R.), Pharmacology (S.K., T.Y., M.E.A., D.M.R.), and Molecular Physiology & Biophysics (K.D.N., M.A.M.), Vanderbilt University School of Medicine, Nashville, Tenn, and Department of Cell Biology and Anatomy (A.W.), Medical University of South Carolina, SC. (At 1999-02-05)