From the Cardiovascular Division (J.N.C.), Department of Medicine, University of Minnesota Medical School, Minneapolis, Minn; VA Medical Center (I.S.A.), Minneapolis, Minn; Istituto “Mario Negri” (R.L., S.M.), Milan, Italy; and Novartis Pharmaceuticals Corporation (Y.-T.C., R.G.), East Hanover, NJ. (At 2003-09-16)