1Cancer Epigenetics and Biology Program and 2Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, L'Hospitalet, and 3Institució Catalana de Recerca i Estudis Avançats, Catalonia, Spain; and 4First Department of Internal Medicine, Sapporo Medical University School of Medicine and 5Sapporo Medical University, Sapporo, Japan (At 2009-10-28)