Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, INSERM U-524 and Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, Place de Verdun, F-59045 Lille, France, and Faculty of Engineering and Faculty of Fisheries, Nagasaki University, Nagasaki 852-8521, Japan (At 2005-05-03)