From the Departments of Cardiovascular Medicine (K.O., K.E., M.U., Q.Z., S.K., M.I., K.-i.H., S.I., K.S.) and Pathology (Y.Y., S.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka; the Department of Cardiovascular Medicine (M. Sata), Graduate School of Medical Sciences, University of Tokyo, Tokyo; and the Division of Genetics (M. Shibuya), Institute of Medical Science, University of Tokyo, Tokyo, Japan. (At 2004-10-19)