From the Department of Biochemistry and Integrative Medical Biology (M.I., M.K., T.A., K.M., N.M., N.G., M.S.) and Department of Neurosurgery (M.I.), School of Medicine, Keio University, Tokyo, Japan; Department of Molecular Genetics and Biochemistry (T.Y.), Tokyo Medical and Dental University, Japan; and Department of Internal Medicine (M.I., E.S.), Saitama National Hospital, Japan. (At 2005-12-09)