ベンゾジアゼピン系マイナートランキライザーの逆相薄層クロマトグラフィー

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書誌事項

タイトル別名
  • Separation of benzodiazepine minor tranquilizers by means of reversed-phase thin-layer chromatography
  • ベンゾジアゼピンケイ マイナートランキ ライザー ノ ギャクソウ ハクソウ ク

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抄録

Reversed-phase thin-layer chromatographic separation of twelve kinds of benzodiazepine minor tranquilizers was studied by using two kinds of chemical bonding alkylsilyl silica gel (dimethylsilyl silica gel and octadecylsilyl silica gel) as stationary phase and three kinds of organic solvents (methanol, acetone and dioxane) containing water as mobile phase. The compounds tested were benzodiazepine, medazepam, chlordiazepoxide, estazolam, triazolam (3-H-1, 4-benzo-diazepine), chloxazolam, flurazepam, diazepam, chlordiazepam, nimetazepam, lorazepam and nitrazepam (1, 3-dihydro-2H-1, 4-benzodiazepine-2-one). When dimethylsilyl silica gel was used as stationary phase for the separation of these minor tranquilizers, methanol-water (2 : 1) was more effective than acetone and dioxane. Octadecylsilyl silica gel gave better separation than dimethylsilyl silica gel when the mobile phase (methanol-water=2:1 or 3:1) added with ammonium hydroxide was used. Thus, the reversed-phase thin-layer chromatography with chemical bonding alkylsilyl silica gels as stationary phase seems to have wide applications in the separation of various pharmaceuticals including benzodiazepine minor tranquilizers, cephalosporin antibiotics {T.Okumura : Bunseki Kagaku, 26, 848 (1977)} and steroidal hormones {T. Okumura, A. Azuma : Bunseki Kagaku, 28, 235 (1979)}.

収録刊行物

  • 分析化学

    分析化学 28 (10), 584-587, 1979

    公益社団法人 日本分析化学会

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