アセトニトリル-水混合溶媒を用いる逆相分配液体クロマトグラフ分離系の物質移動特性

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タイトル別名
  • Mass-transfer properties of reversed-phase portion LC with an acetonitrile-water mobile phase.
  • アセトニトリル‐水混合溶媒を用いる逆相分配液体クロマトグラフ分離系の物質移動特性
  • アセトニトリル ミズ コンゴウ ヨウバイ オ モチイル ギャクソウ ブンパイ

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The adsorption characteristics of reversed-phase liquid chromatography were studied by the chromatographic method and a moment analysis. Octadecylsilyl-silica gel was used as a stationary phase and an acetonitrile-water (70/30, v/v) mixture as a mobile phase. The equilibrium, kinetic, and thermodynamic properties of adsorption phenomena in the system were elucidated, and compared with those in a reversed-phase system using a methanol-water (70/30, v/v) mixed solvent as a mobile phase. The magnitude of the interaction between the adsorbate molecules and octadecyl ligands in 70 vol.% acetonitrile was weaker than that in 70 vol % methanol. In both adsorption systems, the surface diffusion was dominant for intraparticle diffusion. Surface diffusion phenomena were considered from the viewpoint of the thermodynamic properties. The establishment of an enthalpy-entropy compensation effect was confirmed for surface diffusion phenomena. The differences in the mass-transfer properties in both reversed-phase liquid chromatographic systems were quantitatively elucidated from equilibrium, kinetic, and thermodynamic points of view.

収録刊行物

  • 分析化学

    分析化学 46 (7), 579-586, 1997

    公益社団法人 日本分析化学会

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