Analysis of trace elements in clinical samples by plasma ion source MS.

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  • プラズマイオン源質量分析法によるヒト試料の微量元素分析
  • プラズマ イオンゲン シツリョウ ブンセキホウ ニヨル ヒト シリョウ ノ ビ

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Abstract

Application of plasma ion source mass spectrometry (ICP-MS, ICP-high resolution MS, and N2-MIP-MS) to trace element analysis of clinical samples was described. Multi-element analysis of human organs by ICP-MS provided fairly abundant information on the levels of various trace elements. However, enormous Ca and P matrices of human bone hampered sensitive determination of trace elements in this matrix. Analysis of metals in human serum by ICP-quadrupole MS was thought to be difficult because of the low levels involved and matrix-related problems, i.e., spectral interference and matrix effect, although this did not hold true for the analysis of I in human body fluids. Use of ICP-high resolution MS was found to be promising for sensitive determination of Al, V, Cr and Mn in human serum at their normal levels. Isotope dilution analysis by plasma ion source mass spectrometry was an accurate and precise analytical method and it has been used for the certification of Hg and Se concentrations in a candidate reference material (human hair). Micro sampling followed by flow injection ICP-MS revealed that the distribution profile of T1 along single strands of hair allows reconstruction of the recent past history of exposure in a poisoned patient.

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 44 (11), 895-903, 1995

    The Japan Society for Analytical Chemistry

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