二塩基酸染料,キニーネ及び第四級アンモニウムイオンの三元イオン会合性に基づく医薬品中の陽イオン系消毒剤の抽出-吸光光度定量(<特集>医薬品の分析)

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タイトル別名
  • Extraction-spectrophotometric determination of cationic disinfectants in drugs based on ternary ion association among diprotic acid dyes, quinine and quaternary ammonium ions.
  • 二塩基酸染料，キニーネ及び第四アンモニウムイオンの三元イオン会合性に基づく医薬品中の陽イオン系消毒剤の抽出‐吸光光度定量
  • 2エンキサン センリョウ キニーネ オヨビ ダイ 4キュウ アンモニウム イオ

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The sensitive and selective method described here is based on the reaction of monovalent cation of quinine (HQ+) and quaternary ammonium ion (R4N+) with divalent anion (A2-) of diprotic acid dye, such as Bromochlorophenol Blue (BCPB) or Bromocresol Purple(BCP), to form a 1 : 1 : 1 ternary ion association complex (R4N+·HQ+·A2-) extractable into 1, 2-dichloroethane at nearly pH 7. Berberine and cetylpyridinium ion could be extracted in large amounts into 1, 2-dichloroethane with the above dyes only in the presence of quinine. Other amines and some kinds of quaternary ammonium ions were not extracted. Accordingly, the formation of R4N+·HQ+·A2-might enhance extractability and selectivity of berberine and cetylpyridinium ion. Molar absorptivities were 4.99 × 104 mol-1 cm-1 1 for berberine-quinine-BCPB associate, 1.24 × 104for berberine-quinine-BCP and 4.68 × 104 for cetylpyridinium ion-quinine-BCPB, respectively. These blue associates with BCPB and BCP showed maximum absorbances at 605 and 593 nm, respectively and could be applied in spectrophotometric determination of berberine and cetylpyridinium ion used as cationic disinfectants in drugs.

収録刊行物

  • 分析化学

    分析化学 35 (3), 177-183, 1986

    公益社団法人 日本分析化学会

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