Asymmetric synthesis in aqueous media using highly functionalized resin-supported peptide catalyst

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  • AKAGAWA Kengo
    東京大学生産技術研究所　物質・環境系部門
  • KUDO Kazuaki
    東京大学生産技術研究所　物質・環境系部門

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Other Title
  • 高機能性固定化ペプチド触媒を用いた水系溶媒中での不斉合成
  • コウキノウセイ コテイカ ペプチド ショクバイ オ モチイタ スイケイ ヨウバイ チュウ デ ノ フセイ ゴウセイ

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Abstract

Efficient systems for catalytic asymmetric syntheses in aqueous media have been developed by using amphiphilic-resin-supported hydrophobic peptides having terminal prolyl groups. The supported peptide catalysts can be easily synthesized through the conventional solid-phase method, and have some merits such as reusability, applicability to sequential reactions, and facility for optimizing peptide sequences. The catalytic systems in aqueous media with the supported peptides are expected to provide the efficient procedures for the production of chiral fine chemicals.

Journal

  • SEISAN KENKYU

    SEISAN KENKYU 62 (3), 219-224, 2010

    Institute of Industrial Science The University of Tokyo

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