Current Status and Perspective of Intracorporeal Liver Tissue Engineering at Heterotopic Transplantation Sites

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  • 異所性体内埋め込み型人工肝臓開発の現状と展望
  • イショセイ タイナイ ウメ コミ ガタ ジンコウ カンゾウ カイハツ ノ ゲンジョウ ト テンボウ

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Abstract

Heterotopic transplantation of a bioengineered liver tissue represents an attractive alternative to orthotopic liver transplantation. Important issues in heterotopic liver tissue engineering field fall into three major factors: (1) vascularization in the bioengineered tissue, (2) selection of an appropriate site for the growth and reconstruction of the liver tissue, and (3) availability of sufficient mass of hepatocytes. Herein, we showed solutions to these issues. In addition, we described a transplantation methodology of bioengineered liver tissues onto the mesentery as a typical example of the heterotopic transplantation.

Journal

  • SEISAN KENKYU

    SEISAN KENKYU 62 (3), 213-217, 2010

    Institute of Industrial Science The University of Tokyo

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