放射光を利用したタンパク質結晶ダイナミクス研究の動向

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  • 足立 伸一
    高エネルギー加速器研究機構・物質構造科学研究所科学技術振興機構・ERATO腰原非平衡ダイナミクスプロジェクト

書誌事項

タイトル別名
  • Feasibility and Instrumentations of Protein Dynamics Research with Protein Crystallography and Synchrotron Radiation
  • ホウシャコウ オ リヨウ シタ タンパクシツ ケッショウ ダイナミクス ケンキュウ ノ ドウコウ

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抄録

Proteins are encoded in genes in living organisms and play a wide variety of functions in life. X-ray crystallographic technique has provided a solid base for understanding their 3-D architecture. However, relatively little information has been extracted from these studies about their dynamics, because the 3-D structural information is essentially static. In order to understand the mechanistic details of how proteins function, it is crucial to know the dynamics of events that give rise to their designed functions. Recent progress in cryogenic techniques and/or time-resolved X-ray diffraction at synchrotron radiation facilities enables“watching”the collective motions of proteins that closely related to the protein functions. Here I review the instrumentations and feasibility of the protein dynamics research with protein crystallography.

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