Structural Biology of Nucleic-Acid Recognition and its Roles in Regulation of Protein Functions

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  • HAKOSHIMA Toshio
    Stuructural Biology Laboratory, Graduate School of Information Science, Nara Institute of Science and Technology CREST Japan Science and Technology Agency

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  • 核酸分子認識とその機能を中心とした構造生物学
  • ソウゴウ ホウコク ニホン ケッショウ ガッカイショウ ジュショウ ロンブン カクサン ブンシ ニンシキ ト ソノ キノウ オ チュウシン ト シタ コウゾウ セイブツガク

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Abstract

Crystallographic studies on nucleic acid-nucleic acid, nucleic acid-protein and protein-protein interactions are reviewed. The studies contain base pairing, sequence-specific stability of Z-DNA structures, base recognition by ribonuclease T1, transcriptional factors-DNA interaction, G proteins and the effector protein recognition, and protein-protein interactions in intracellular signaling pathways.

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