A Novel Mode of Target Recognition Suggested by the 2.0 .ANGS. Structure of Holo S 100B from Bovine Brain.

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  • MATSUMURA Hiroyoshi
    Department of Materials Chemistry, Graduate School of Engineering, Osaka University
  • HARADA Shigeharu
    Graduate School of Pharmaceutical Sciences, The Univeristy of Tokyo
  • KAI Yasushi
    Department of Materials Chemistry, Graduate School of Engineering, Osaka University

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  • Ｃａ｀２＋´結合タンパク質Ｓ１００Ｂの結晶構造と分子認識機構
  • サイキン ノ ケンキュウ カラ Ca2 ケツゴウ タンパクシツ S100B ノ ケッショウ コウゾウ ト ブンシ ニンシキ キコウ

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Abstract

The three-dimensional structure of holo S100B from bovine brain has been determined at 2.0 Å resolution by X-ray diffraction. The dimeric S100B molecule is formed by non-covalent interactions between large hydrophobic surface on both S100β subunits. There are two EF-hand motifs per S100β subunit, each of which binds one calcium ion. We observe, in the calcium-bound structure, dramatic changes in the conformation of the terminal helices, from the compact structure in the apo form to a more extended form upon binding calcium. This conformational change suggests a novel mode of target recognition of S100B.

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