書誌事項
- タイトル別名
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- Crystal Structure Analysis of Adenosine A<sub>2A</sub> Receptor in Complex with Functional Antibody Fragment
- 機能性抗体を用いたアデノシンA₂[A]受容体の結晶構造解析
- キノウセイ コウタイ オ モチイタ アデノシン A ₂[A]ジュヨウタイ ノ ケッショウ コウゾウ カイセキ
- Crystal Structure Analysis of Adenosine A2A Receptor in Complex with Functional Antibody Fragment
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抄録
G protein coupled receptors (GPCR) are involved in a wide variety of physiological functions, and thus are the targets for most of today's medicine. Here we report the raising of a monoclonalantibody against human adenosine A2A receptor that works as strong inverse agonist, and describe the crystal structure of the receptor in complex with the antibody fragment. The structure reveals that the antibody specifically recognizes the intracellular surface of thereceptor in an inactivated state so as to inhibit the structural changes to the active conformation. Our results suggest a new strategy to modulate the activity of GPCR.
収録刊行物
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- 日本結晶学会誌
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日本結晶学会誌 55 (2), 103-109, 2013
日本結晶学会
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詳細情報 詳細情報について
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- CRID
- 1390001204088815104
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- NII論文ID
- 10031168498
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- NII書誌ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL書誌ID
- 024694605
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可