Structural Biology of the Food Poisoning <i>Clostridium Perfringens</i> Enterotoxin

DOI Web Site 49 References
  • KITADOKORO Kengo
    Graduate School of Science and Technology, Department of Biomolecular Engineering, Kyoto Institute of Technology
  • NISHIMURA Kousuke
    Graduate School of Science and Technology, Department of Biomolecular Engineering, Kyoto Institute of Technology
  • KAMITANI Shigeki
    Department of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University
  • HORIGUCHI Yasuhiko
    Department of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University

Bibliographic Information

Other Title
  • 食中毒を引き起こすウェルシュ菌エンテロトキシンCPEの構造生物学的研究
  • ショクチュウドク オ ヒキオコス ウェルシュキン エンテロトキシン CPE ノ コウゾウ セイブツガクテキ ケンキュウ
  • Structural Biology of the Food Poisoning Clostridium Perfringens Enterotoxin

Search this article

Description

Clostridium perfringens enterotoxin（CPE）is a cause of food poisoning and is considered a pore-forming toxin which damages target cells by disrupting the selective permeability of the plasma membrane. We determined the crystal structure of the full-length CPE at 2.0 Å. The overall structure of CPE displays an elongated shape, composed of three distinct domains, D1, D2, and D3. In this structure, the pore-forming domain（Val81〜Ile106）of CPE has alternating pattern of polar and hydrophobic residues and forms α-helix. This characteristic sequence is frequently observed in β pore-forming toxin families as typified by α-hemolysin. These results indicate that CPE behaves as β pore-forming toxins.

Journal

References(49)*help

See more

Related Projects

See more

Details 詳細情報について

Report a problem

Back to top