Progress in Transmission Electron Microscopy and its Application to Correlative Analysis
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- IWASAKI Kenji
- Research center for State-of-the-Art Functional Protein Analysis, Institute for Protein Research, Osaka University
Bibliographic Information
- Other Title
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- 電子顕微鏡技術の進展と相関解析
- デンシ ケンビキョウ ギジュツ ノ シンテン ト ソウカン カイセキ
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Description
Recent advances that improve direct electron detectors have revolutionized structural determination of biological molecules by cryo-electron microscopy. It has brought about the advent of near atomic resolution in single-particle reconstruction even with membrane proteins of 200~400 kDa. In fact, such high-resolution structures have allowed de novo building of atomic models. This rapid progress will change the quality and quantity of the conventional hybrid approach combining cryo-electron microscopy and X-ray crystallography or light microscopy, and computational methods such as molecular dynamics will also take on added significance to create integrated models of huge and complex macromolecules.
Journal
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- Nihon Kessho Gakkaishi
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Nihon Kessho Gakkaishi 57 (1), 66-71, 2015
The Crystallographic Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204090038016
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- NII Article ID
- 130004799738
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- NII Book ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL BIB ID
- 026218893
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed