Progress in Transmission Electron Microscopy and its Application to Correlative Analysis

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  • IWASAKI Kenji
    Research center for State-of-the-Art Functional Protein Analysis, Institute for Protein Research, Osaka University

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  • 電子顕微鏡技術の進展と相関解析
  • デンシ ケンビキョウ ギジュツ ノ シンテン ト ソウカン カイセキ

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Abstract

Recent advances that improve direct electron detectors have revolutionized structural determination of biological molecules by cryo-electron microscopy. It has brought about the advent of near atomic resolution in single-particle reconstruction even with membrane proteins of 200~400 kDa. In fact, such high-resolution structures have allowed de novo building of atomic models. This rapid progress will change the quality and quantity of the conventional hybrid approach combining cryo-electron microscopy and X-ray crystallography or light microscopy, and computational methods such as molecular dynamics will also take on added significance to create integrated models of huge and complex macromolecules.

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