Synthesis and Physiological Activity of Toluyl Esters from 5-Methyl-2-Phenyl-2-Hexenal Derivatives

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  • 5-メチル-2-フェニル-2-ヘキセナールとその類似化合物を出発原料としたトルイル酸エステル誘導体の合成とそれらの生物活性評価
  • 5メチル2フェニル2ヘキセナール ト ソノ ルイジ カゴウブツ オ シュッパツ ゲンリョウ ト シタ トルイルサン エステル ユウドウタイ ノ ゴウセイ ト ソレラ ノ セイブツ カッセイ ヒョウカ
  • 生理活性物質の合成に関する研究 (第20報)

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Physiologically active compounds, 5-methyl-2-phenyl-2-hexenal (1) from Idaho potatoes and related compounds, 4-methyl-2-phenyl-2-pentenal (2), 2-methyl-4-phenylpentanal (3) and 2-methyl-2-pentenal (4) were synthesized and used as starting compounds for the synthesis of twenty-one compounds through condensation with o-, m- and p-toluoyl chlorides. The derivatives obtained were examined for capacity as whitening agents and growth-regulation. (4h) derived from (4) were found to be inhibited by tyrosinase by 71%. This inhibitory action considerably exceeded that of arbutin used in commercial cosmetics. Seventeen derivatives were found effective for weed control in a field (50g/a), and showed particularly strong inhibitory action forward growth of Monochoria vaginalis.

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