Elaidic Acid and Oleic Acid Have Opposite Effects on Serum Glucose, Insulin and Immunoglobulin Levels and Eicosanoid Production in Streptozotocin-Induced Diabetic Rats
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- KOGA Tamiho
- Nakamura Gakuen Junior College
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- GU Jong-Yan
- Division of Applied Biological Chemistry, Faculty of Agriculture, Graduate School Kyushu University
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- NONAKA Michiko
- Division of Applied Biological Chemistry, Faculty of Agriculture, Graduate School Kyushu University
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- SUGANO Michihiro
- Professor Emeritus, Kyushu University and Prefectural University of Kumamoto
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The present study was designed to evaluate the physiological effect of trans fatty acid in the diabetic condition. After feeding the mixture of oleic (cis) or elaidic (trans) acids with safflower oil (3 : 7, wt/wt) at the dietary level of 10% for 2 weeks, rats were treated with streptozotocin and reared on the same diets for an additional week. The dietary level of elaidic acid was 6.4 energy %, which corresponded to the level that causes an increase in plasma low-density lipoprotein cholesterol and a decrease in high-density lipoprotein cholesterol in humans. The following differences were observed in rats fed trans acid in comparison with those fed cis acid; (a) significant reduction of water consumption and serum glucose, and an elevation of serum insulin, (b) a reducing trend of serum and liver lipids, (c) a reducing trend of the proportion of stearic and arachidonic acids in liver phospholipids and (d) a significant reduction of the concentration of serum immunoglobulin G (IgG) and an increase in IgE. Thus, the results indicate that elaidic acid may not further aggravate metabolic disorders caused under the diabetic condition more than the cis counterpart even when consumed at a relatively high level, with the exception of the response of serum immunoglobulins.<br>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 55 (3), 127-134, 2006
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204090641920
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- NII論文ID
- 130000055576
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 7817759
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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