n-3系高度不飽和脂肪酸と骨代謝

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  • 日比野 英彦
    日本油脂株式会社 食品カンパニー営業本部
  • 森田 育男
    東京医科歯科大学 大学院医歯学総合研究科分子細胞機能学分野

書誌事項

タイトル別名
  • N-3 Polyunsaturated Fatty Acids and Bone Metabolism
  • n 3ケイ コウド フホウワ シボウサン ト コツ タイシャ EPA ノ ユウエキ ナ コウカ
  • Beneficial Effects of Eicosapentaenoic Acid
  • EPAの有益な効果

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抄録

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), n-3 polyunsaturated fatty acid (n-3PUFA), have been shown to have beneficial effects on what? The beneficial effects of n-3PUFA, especially EPA on bone metabolism in vitro and in vivo were examined in this study.<BR>Osteoblasts are bone forming cells, that produce prostaglandin E2, an endogenous potent bone resorbing factor. To clarify the effects of EPA on bone metabolism, the effects of EPA on MC3T3-E1 cells, osteoblast-like cells were studied. The addition of MC3T3-E1 cells to EPA, but not DHA, caused increased calcium accumulation and Von-Kossa staining. In vivo experiments, the effect of EPA on strength of the femur in ovariectomized and low calcium/vitamin D3 fed rats were studied. EPA abolished the effects of ovariectomy with consequent recovery of the bone strength.<BR>Preliminary epidemiology studies indicate EPA ingestion possibly useful for preventing loss of bone weight and strength with aging. These findings and epidemiological studies, demonstrate EPA and marine oil to possibly have beneficial effects for preventing and improving age-related osteoporosis

収録刊行物

  • 日本油化学会誌

    日本油化学会誌 49 (11-12), 1391-1399,1446, 2000

    公益社団法人 日本油化学会

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