Self-aggregates of Highly Hydrophobic Phospholipid Polylmers in Aqueous Solution
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- YAMAMOTO Nobuyuki
- Section II, Tsukuba Corporate Research Laboratory, Life Science Products Division, NOF Corporation Graduate School of Natural Science & Technology, Kanazawa University
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- IRIE Hirofumi
- Section II, Tsukuba Corporate Research Laboratory, Life Science Products Division, NOF Corporation
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- SAKAMOTO Nobuyuki
- Section II, Tsukuba Corporate Research Laboratory, Life Science Products Division, NOF Corporation
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- SHUTO Kenshiro
- Section II, Tsukuba Corporate Research Laboratory, Life Science Products Division, NOF Corporation
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- YAMAGISHI Tada-Aki
- Graduate School of Natural Science & Technology, Kanazawa University
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- NAKAMOTO Yoshiaki
- Graduate School of Natural Science & Technology, Kanazawa University
書誌事項
- タイトル別名
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- Self-aggregates of Highly Hydrophobic Phospholipid Polymers in Aqueous Solution
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説明
In this study, the authors produced self-aggregates of highly hydrophobic phospholipid polymers consisting of 2-methacryloyloxyethyl phosphorylcholine (MPC) and stearyl methacrylate (SMA). MPC/SMA copolymers (PMS) self aggregated in a solvent consisting of 1-propanol and water (in 1:4 (w/w)). When alcohols other than 1-propanol were used, no homogeneous self-aggregate solution was obtained. The average diameter of PMS self-aggregates varied from 10 to 40 nm depending on the MPC content in PMS. The PMS self-aggregate was stable, and the diameter showed no changes even when the solution was stored at 60°C or 4°C for 3 months. The PMS showed high solubilization ability and solubilized hydrophobic compounds, such as tocopherol acetate and coenzyme Q10, in aqueous solutions. PMS that contained 50 unit mol% of SMA (PMS5050) showed the highest solubilization ability among PMS of different SMA contents. In spite of the high solubilization ability, PMS self-aggregates showed low surface activity and almost no cytotoxicity, showing that the PMS self-aggregates are promising biocompatible solubilizer.<br>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 55 (9), 465-471, 2006
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204090686336
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- NII論文ID
- 130000055541
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
- http://id.crossref.org/issn/13458957
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- NDL書誌ID
- 8019641
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可