Thermophilic Archer and Their Ether Lipids. Early Steps of Biosynthesis of Ether Lipids in Archaebacteria.

DOI Web Site Web Site 29 References
  • NISHINO Tokuzo
    Department of Biochemistry and Engineering, Faculty of Engineering, Tohoku University

Bibliographic Information

Other Title
  • 好熱性古細菌とエーテル脂質　エーテル脂質生合成の初期段階
  • エーテル シシツ セイゴウセイ ノ ショキ ダンカイ

Search this article

Abstract

Archaebacterial membrane lipids are mainly ether-linked lipids in place of the usual membrane ester-linked phospholipids of eubacteria and eukaryotes and enable the organisms to inhabit extreame environments. These lipids are composed of a glycerol group and saturated isoprenoid moieties with 20 or 40 carbon atoms. It is proposed that geranylgeranyl diphosphate, which is synthesized by a cytosolic geranylgeranyl diphosphate synthase or geranylgeranyl phosphate kinase, is attached to glyceryl phosphate, followed by saturation of the geranylgeranyl moieties to make phytanyl group and head-to-head dimerization to produce C40 etherlinked lipids.<BR>The gene of geranylgeranyl diphosphate synthase in Sulfolobus acidocaldarius was isolated by the method of red-white screening system.<BR>Compared with other genes of isoprenyl diphosphate synthase, some discussion of evolution was made.

Journal

References(29)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top