Condensation Reaction of <I>Trans</I>-Anethole Derivatives with Several Monoterpenyl Compounds and Their Inhibition Properties towards Tyrosinase, Superoxide Scavenging Activity and Hyaluronidase Activity

DOI Web Site Web Site 2 Citations 12 References Open Access
  • NOMURA Masato
    Department of Chemistry and Environmental Technology, Faculty of Engineering, Kinki University
  • NISHIMURA Kazuhiko
    Department of Chemistry and Environmental Technology, Faculty of Engineering, Kinki University
  • FUJIHARA Yoshihito
    Department of Chemistry and Environmental Technology, Faculty of Engineering, Kinki University
  • TADA Takahiro
    Research and Development Division, Mikimoto pharmaceutical & Co., Ltd.
  • HATTORI Fumihiro
    Research and Development Division, Mikimoto pharmaceutical & Co., Ltd.
  • SHIMOMURA Kenji
    Research and Development Division, Mikimoto pharmaceutical & Co., Ltd.

Bibliographic Information

Other Title
  • <I>Trans</I>-アネトール誘導体と数種のモノテルペニル化合物との縮合反応ならびにチロシナーゼ活性阻害, 活性酸素抑制効果およびヒアルロニダーゼ活性阻害について
  • Trans アネトール ユウドウタイ ト スウシュ ノ モノテルペニル カゴウブツ ト ノ シュクゴウ ハンノウ ナラビニ チロシナーゼ カッセイ ソガイ カッセイ サンソ ヨクセイ コウカ オヨビ ヒアルロニダーゼ カッセイ ソガイ ニ ツイテ
  • 生理活性物質の合成に関する研究 (第22報)

Search this article

Description

Natural material extracts are presently used as cosmetic ingredients. Physiological effects were examined, using trans-anethole (1) from Foeniculum vnlgar MILL as starting material. Eight derivatives were synthesized by oximation (N, N-diethyl hydrazonation, methylation and elimination reaction), LiAlH4 mediated reaction, with chloroacetyl chloride and condensation with four terpenyl amines to confirm efficiency as whitening agents, inhibitory activities towards tyrosinase, superoxide scavenging activity or hyaluronidase activity. Compounds (9a), (9b) and (9c) derived from (4) were found to be inhibited by ca. 5561% in tyrosinase (Dopa) activity. The inhibitory rates exceeded that of arbutin used for commercial cosmetics (Arbutin), (9c) or (10b), and the superoxide scavenging activity was noted to be inhibited by more than ca. 33%.

Journal

Citations (2)*help

See more

References(12)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top