Characterization of the Physicochemical Properties of the Micelle of the Novel Platelet Factor Receptor Antagonist, E5880.
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- ASAI Yasuyuki
- Formulation Research Laboratory, Kawashima, Eisai Co., Ltd.
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The injectable formulation of E5880, a novel platelet factor (PAF) receptor antagonist, was developed. The physicochemical properties of E5880 micelles in the optimized formulation (0.6 mg/ml of E5880, 0.1% citric acid, 10% lactose, pH 2.8) were characterized. The critical micelle concentration of E5880 was 0.09 mg/ml, and the structure was spherical. The micelle size was 5.6 nm. The number of the molecules per micelle was 46. The micropolarity around the hydrocarbon region in the micelle was similar to that of isobutanol.<br>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 52 (4), 191-196, 2003
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204091115904
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- NII論文ID
- 130000060322
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- NII書誌ID
- AA11503337
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- COI
- 1:CAS:528:DC%2BD3sXjtlOlsrY%3D
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 6483135
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可