Preventive Effect of Eye Drops of Liposomes Containing Disulfiram and Cefmetazole on Selenite-Induced Cataract in Rat Pups
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- ITO Yoshimasa
- School of Pharmaceutical Sciences, Kinki University Pharmaceutical Research and Technology Institute, Kinki University
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- NAGAI Noriaki
- School of Pharmaceutical Sciences, Kinki University
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- CAI Hong
- School of Pharmaceutical Sciences, Kinki University
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- TAKEDA Maki
- School of Pharmaceutical Sciences, Kinki University
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- KOIZUMI Yuichi
- School of Pharmaceutical Sciences, Kinki University
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Abstract
Disulfiram (DSF) and cefmetazole (CMZ), which possess with anti-oxidative activities were tested for anti-cataract effect in rats and were compared with pirenoxine (PRX), which is a marketed product used for the treatment of cataract. These compounds were encapsulated in liposomes and the results were compared with the anti-cataract effect of suspension and solution formulations containing same contents of each other agents. Instillations of DSF- and CMZ-liposomes prevented the development of cataract in selenite-injected rat pups. On the other hand, no anti-cataract effects were observed in selenite-induced cataract rats instilled with DSF suspensions and CMZ solutions. The reduced form of glutathione (GSH) content of the lenses was decreased by approximately 60% of normal level 96 h after the sodium selenite-injection and the calcium (Ca2+) content was increased. The decreased GSH and increased Ca2+ levels were prevented by instillation of DSF- and CMZ-liposomes. Instillation of PRX-liposomes and 0.03% PRX solution had no effect on the development of cataract. The results of this study confirmed that anti-oxidative agents such as DSF and CMZ were useful to prevent cataract development related to oxidative stress.<br>
Journal
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- Journal of Oleo Science
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Journal of Oleo Science 55 (1), 15-22, 2006
Japan Oil Chemists' Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204091172992
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- NII Article ID
- 130000055608
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- NII Book ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL BIB ID
- 7747100
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed