Preparation and Properties of Nanosized Biodegradable Polymer Capsules

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  • Sakai Hideki
    Faculty of Science and Technology, Tokyo University of Science Research Institute of Science and Technology, Tokyo University of Science
  • Sekita Ayasa
    Faculty of Science and Technology, Tokyo University of Science
  • Tanaka Keisuke
    Faculty of Science and Technology, Tokyo University of Science
  • Sakai Kenichi
    Faculty of Science and Technology, Tokyo University of Science
  • Kondo Tamotsu
    Faculty of Science and Technology, Tokyo University of Science
  • Abe Masahiko
    Faculty of Science and Technology, Tokyo University of Science Research Institute of Science and Technology, Tokyo University of Science

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This article reports the preparation and properties of nanosized biodegradable polymer capsules synthesized using the electrocapillary emulsification method. The biodegradable polymers used were poly(ε-caprolactone) (PCL), which is a highly biodegradable and biocompatible polymer, and poly(lactide-co-glycolic acid) (PLGA). While the size of the capsules prepared using PCL alone was in the micrometer range, it decreased with an increase in the amount of PLGA added to PCL and eventually reached the nanometer level. When the electrocapillary emulsification applied potential was 2000 V, the sizes of the capsules (PCL:PLGA = 5:5) ranged from 50 to 80 nm. The percentage of glucose trapped in the PCL/PLGA nanocapsules was higher than 80% and the duration of glucose release from the nanocapsules was about two times longer than that from PCL capsules.

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