Synthesis and Antibacterial Activity of α-Methylene-γ-alkylbutyrolactones
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- TONARI Kennosuke
- Course of Industrial Chemistry, Kinki Polytechnic College
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- KANOH Aya
- Course of Industrial Chemistry, Kinki Polytechnic College
書誌事項
- タイトル別名
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- Synthesis and Antibacterial Activity of .ALPHA.-Methylene-.GAMMA.-alkylbutyrolactones.
- Synthesis and Antibacterial Activity of アルファ Methylene ガンマ alkylbutyrolactones
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説明
α-Methylene-γ-alkylbutyrolactones were synthesized by usual method and assessed for antibacterial activity against Bacillus subtilis and Escherichia coli. Using substituent constants (π) of the compounds, regression analysis was made on the effect of alkyl side chains of the methylenelactones. The correlation coefficient (r) between observed and calculated minimum inhibitory concentration (MIC) expressed in molar concentration as log(1/C) was 0.739 and 0.725 for B. subtilis and for E. coli, respectively. On using steric parameter of E’s, r was up to 0.894 and 0.884 for B. subtilis and E. coli, respectively. Consideration of π derived from the smallest MIC, α-methylene-γ-nonalactone 6 or α-methylene-γ-decanolactone 7 suggested the strongest antibacterial activity.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 51 (4), 251-254, 2002
公益社団法人 日本油化学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001204091811200
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- NII論文ID
- 10007819104
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- NII書誌ID
- AA11503337
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- COI
- 1:CAS:528:DC%2BD38Xitl2rs7k%3D
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 6110690
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
