Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)

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  • YAGI Nobuo
    Picaso Cosmetic Laboratory Limited
  • OHKUBO Katsuya
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
  • OKUNO Yoshiharu
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
  • ODA Yoshimitsu
    Osaka Prefectural Institute of Public Health
  • MIYAZAWA Mitsuo
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

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Abstract

A ethanol extract from Yellow batai (Peltophorum dasyrachis) showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium OY1001/1A2 against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). The ethanol exract was re-extracted with chloroform, ethylacetate, butanol, and water. A chloroform fraction showed a suppressive effect. Suppressive compound against MeIQ in the chloroform fraction was isolated by SiO2 column chromatography and identified as surangin C (1) by FABMS, EIMS, and 1 D and 2 D NMR spectroscopy. Surangin C exhibited an inhibition of the SOS-inducing activity of MeIQ in the umu test. Gene expression was suppressed 59.5% at a concentration of 100 μM. The ID50 value (50% inhibition dose) of compound 1 was 67.9 μM. On the other hand, compound 1 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ.<br>

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