Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)

  • YAGI Nobuo
    Picaso Cosmetic Laboratory Limited
  • OHKUBO Katsuya
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
  • OKUNO Yoshiharu
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
  • ODA Yoshimitsu
    Osaka Prefectural Institute of Public Health
  • MIYAZAWA Mitsuo
    Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University

この論文をさがす

抄録

A ethanol extract from Yellow batai (Peltophorum dasyrachis) showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium OY1001/1A2 against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). The ethanol exract was re-extracted with chloroform, ethylacetate, butanol, and water. A chloroform fraction showed a suppressive effect. Suppressive compound against MeIQ in the chloroform fraction was isolated by SiO2 column chromatography and identified as surangin C (1) by FABMS, EIMS, and 1 D and 2 D NMR spectroscopy. Surangin C exhibited an inhibition of the SOS-inducing activity of MeIQ in the umu test. Gene expression was suppressed 59.5% at a concentration of 100 μM. The ID50 value (50% inhibition dose) of compound 1 was 67.9 μM. On the other hand, compound 1 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ.<br>

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (3)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ