Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)
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- YAGI Nobuo
- Picaso Cosmetic Laboratory Limited
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- OHKUBO Katsuya
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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- OKUNO Yoshiharu
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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- ODA Yoshimitsu
- Osaka Prefectural Institute of Public Health
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- MIYAZAWA Mitsuo
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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説明
A ethanol extract from Yellow batai (Peltophorum dasyrachis) showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium OY1001/1A2 against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). The ethanol exract was re-extracted with chloroform, ethylacetate, butanol, and water. A chloroform fraction showed a suppressive effect. Suppressive compound against MeIQ in the chloroform fraction was isolated by SiO2 column chromatography and identified as surangin C (1) by FABMS, EIMS, and 1 D and 2 D NMR spectroscopy. Surangin C exhibited an inhibition of the SOS-inducing activity of MeIQ in the umu test. Gene expression was suppressed 59.5% at a concentration of 100 μM. The ID50 value (50% inhibition dose) of compound 1 was 67.9 μM. On the other hand, compound 1 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ.<br>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 55 (4), 173-180, 2006
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204092214016
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- NII論文ID
- 130000055570
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- NII書誌ID
- AA11503337
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- COI
- 1:CAS:528:DC%2BD28XjtVahur0%3D
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 7849770
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可