High Fat and High Cholesterol Diet Induces DPP-IV Activity in Intestinal Lymph
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- Toyozaki Miku
- Department of Lifesciences and Bioethics, Tokyo Medical and Dental University Institute of Environmental Science for Human life, Ochanomizu University
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- Osaka Mizuko
- Department of Lifesciences and Bioethics, Tokyo Medical and Dental University
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- Kondo Kazuo
- Institute of Environmental Science for Human life, Ochanomizu University
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- Yoshida Masayuki
- Department of Lifesciences and Bioethics, Tokyo Medical and Dental University
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Recent studies have reported that dipeptidyl-peptitase IV (DPP-IV) is correlated with diabetic conditions and also with dyslipidemia caused by overnutrition, especially a high fat diet. However, the role of DPP-IV in diabetes during dyslipidemia has been unclear. We utilized a lymph fistula rat model to determine whether intestinal lymph, which absorbs dietary fats, is affected by a chronic high-fat and high-cholesterol diet (HFHC). HFHC diet rats showed significantly higher DPP-IV activity in intestinal lymph and plasma compared to rats receiving a normal chow diet. In addition, HFHC diet rats showed significantly increased DPP-IV mRNA expression in the intestine. However, DPP-IV mRNA in the lymphocytes isolated from intestinal lymph and mesenteric lymph nodes did not show significant differences from that in the normal diet rats. In conclusion, HFHC diets increased DPP-IV expression in intestinal lymph; these results indicate the applicability of a previously unrecognized role for DPP-IV in metabolic disorders, including diabetes.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 62 (4), 201-205, 2013
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204092277632
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- NII論文ID
- 130004436032
- 40019612024
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- NII書誌ID
- AA11503337
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- COI
- 1:STN:280:DC%2BC3srgtlOjsQ%3D%3D
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 024345404
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- PubMed
- 23535306
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可