The melanogenesis-inhibitory, anti-inflammatory, and chemopreventive effects of limonoids in n-Hexane extract of Azadirachta indica A. Juss. (neem) seeds
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- Akihisa Toshihiro
- College of Science and Technology, Nihon University
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- Takahashi Akitomo
- College of Science and Technology, Nihon University
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- Kikuchi Takashi
- College of Science and Technology, Nihon University
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- Takagi Mio
- College of Science and Technology, Nihon University
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- Watanabe Kensuke
- College of Science and Technology, Nihon University
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- Fukatsu Makoto
- College of Science and Technology, Nihon University
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- Fujita Yukiko
- Ichimaru Pharcos Company Ltd.
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- Banno Norihiro
- Ichimaru Pharcos Company Ltd.
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- Tokuda Harukuni
- Department of Complementary and Alternative Medicine, R&D, Graduate School of Medical Science, Kanazawa University
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- Yasukawa Ken
- School of Pharmacy, Nihon University
書誌事項
- タイトル別名
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- The Melanogenesis-Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids in <i>n</i>-Hexane Extract of <i>Azadirachta indica</i> A. Juss. (Neem) Seeds
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抄録
Seventeen limonoids (tetranortriterpenoids 1-17) were isolated from the n-hexane extract of Azadirachta indica (neem) seeds. The previously unidentified compound 16 was established by spectroscopy to be 17-defurano-17-oxosalannin. The effects of six compounds, 6 and 11-15, on melanogenesis in B16 melanoma cells was evaluated; 2 compounds, salannin (13) and 3-deacetylsalannin (15), exhibited marked inhibitory effects (70-74% reduction of melanin content at 25 μg/mL) with only minor cytotoxicity (79-85% of cell viability). Eleven compounds, 2, 3, 5, 6, and 9-15, were evaluated for inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1.7 nmol/ear) in mice; all exhibited marked anti-inflammatory activity (ID50 values 0.22-0.57 μmol/ear). In addition, compounds 6 and 11-16 exerted moderate inhibition (IC50 values of 410-471 mol ratio/32 pmol TPA) of TPA-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells. The triacylglycerol fraction of the n-hexane extract contained oleic acid (50.2%) as the most predominant fatty acid constituent.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 60 (2), 53-59, 2011
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204092402688
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- NII論文ID
- 130000438327
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 10942718
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可