Interaction between .ALPHA.-Tocopherol, Tocotrienols and Astaxanthin in Liposomes, Subjected to Lipid Peroxidation
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- RANEVA Violeta G.
- 1<sup>st</sup>Biochemistry Department, Teikyo University School of Medicine Lipid Chemistry Department, Institute of Organic Chemistry, Bulgarian Academy of Sciences
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- SHIMASAKI Hiroyuki
- 1<sup>st</sup>Biochemistry Department, Teikyo University School of Medicine
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- UETA Nobuo
- 1<sup>st</sup>Biochemistry Department, Teikyo University School of Medicine
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- TAKAHASHI Jiro
- Fuji Chemical Industry Co., Ltd.
Bibliographic Information
- Other Title
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- Interaction between α-Tocopherol, Tocotrienols and Astaxanthin in Liposomes, Subjected to Lipid Peroxidation
- Interaction between アルファ Tocopherol Tocotrienols and Astaxanthin in Liposomes Subjected to Lipid Peroxidation
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Abstract
We studied the cooperative interaction between α-tocopherol, tocotrienols and astaxanthin, incorporated in soybean phosphatidylcholine (PC) multilamellar vesicles (MLV) against 2,2′-azobis (2-amidinopropane) dihydrochloride (AAPH), 2,2′-azobis (2,4-dimethyl-valeronitrile) (AMVN), or 1,3-morpholinosydnonimine hydrochloride (SIN-1) induced lipid peroxidation. Tocotrienols spared α-tocopherol consumption in hydrophilic or lipophylic radicals initiated oxidation. The combination of tocotrienols and astaxanthin had the greatest protective effect on α-tocopherol consumption in MLV, oxidized by the hydrophilic radical initiator. α-Tocopherol and tocotrienols protected astaxanthin against AAPH-, AMVN-, and SIN-1-induced oxidations. In the three oxidations α-tocotrienol was consumed first, followed by α-tocopherol and the tocotrienols in the sequence: β > γ > δ. Astaxanthin was consumed as fast as γ-tocotrienol in AAPH oxidation, as fast as α-tocopherol in AMVN oxidation, and before δ-tocotrienol in SIN-1 oxidation. In conclusion, α-tocopherol, tocotrienols, and astaxanthin cooperated in protecting against MLV lipid peroxidation. α-Tocotrienol was the most effective antioxidant among them. Astaxanthin was as effective as the chain-breaking antioxidants against lipid peroxidation.<br>
Journal
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- Journal of Oleo Science
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Journal of Oleo Science 52 (7), 347-352, 2003
Japan Oil Chemists' Society
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Details 詳細情報について
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- CRID
- 1390001204092892032
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- NII Article ID
- 10011206117
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- NII Book ID
- AA11503337
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- COI
- 1:CAS:528:DC%2BD3sXkvFCkurY%3D
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- ISSN
- 13473352
- 13458957
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- NDL BIB ID
- 6567483
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed