Strictural analysis and adsorbability onto the corneal epithelial cells-model interface of vitamin nano-emulsion

DOI Web Site Web Site PubMed 被引用文献2件 参考文献20件 オープンアクセス
  • Matsuki Maiko
    Functional Materials Science Research Laboratories, R & D, LION CORPORATION
  • Miyake Miyuki
    Functional Materials Science Research Laboratories, R & D, LION CORPORATION
  • Ogura Taku
    Functional Materials Science Research Laboratories, R & D, LION CORPORATION
  • Hyodo Ryo
    Functional Materials Science Research Laboratories, R & D, LION CORPORATION
  • Tobori Norio
    Functional Materials Science Research Laboratories, R & D, LION CORPORATION
  • Sakai Hideki
    Faculty of Science and Technology, Tokyo University of Science
  • Glatter Otto
    Department of Chemistry, University of Graz

書誌事項

タイトル別名
  • Structural Analysis and Adsorbability onto the Corneal Epithelial Cells-Model Interface of Vitamin Nano-Emulsions

この論文をさがす

説明

O/W nano-emulsions can be used as effective drug carriers of hydrophobic active ingredients in an aqueous solution, because nano-emulsions are comparatively stable and their structure can be controlled by changing the compositions and the preparation methods. In this paper, we focused on vitamin A and its derivatives (VA), which are among the widely-used lipophilic active ingredients, and tried to develop the nano-emulsions, which can bring out the efficiency of VA for the healing of injured corneas, with the detailed structural analysis of them using the small-angle X-ray scattering (SAXS) method. As a result, we elucidated that the nano-emulsions bearing the hydrophobic oil/water interface can be prepared by decreasing the surfactant concentration against vitamins. Moreover, we clarified that the nano-emulsions composed of lower surfactant concentration tend to adsorb VA onto the corneal epithelial cells-model interface. Therefore it is necessary to prepare the nano-emulsions, which have the hydrophobic oil/water interface for improving the adsorbability onto cell membranes.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (20)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ