糖脂質ＧＭ３の機能解明に向けて　　生合成阻害剤の活用

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書誌事項

タイトル別名
  • Toward the Understanding of Glycolipid GM3 Functions. Application of Metabolic Inhibitors.
  • トウ シシツ GM3 ノ キノウ カイメイ ニ ムケテ セイゴウセイ ソガイザ
  • Application of Metabolic Inhibitors
  • 生合成阻害剤の活用

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説明

Glycolipid GM3 increases with cell density of cell growth. GM3 of the plasma membrane is an important modulator of cellular functions of growth. Partial turnover of GM3 is regulated by the presence of the terminal sialic acid moiety. The activities of GM3-metabolizing enzymes i.e. sialidase or sialyltransferase change in the dividing cells. Both enzymes function in the growth control of cells with GM3-mediated inhibition of epidermal growth factor receptor phosphorylation. 2-Deoxy-2, 3-dehydro-N-acetylneuraminic acid (NeuAc2en) is a potent GM3 sialidase inhibitor, which resultantly shows the cell-growth inhibitory effect. Rational, computer-assisted drug design of NeuAc2en derivatives (strong inhibitors) was applied in the development of a new therapeutic treatment for influenza virus infection. CMP-NeuAc is known to produce NeuAc2en spontaneously in the physiological condition. Resultant NeuAc2en might regulate cellular sialidase activity. To further clarify cellular functions of GM3 sialidase or sialyltransferase, it is necessary to design new type of NeuAc2en or CMP-NeuAc derivatives, targeted on the subcellular site of the enzymes.

収録刊行物

  • 日本油化学会誌

    日本油化学会誌 46 (10), 1075-1086, 1997

    公益社団法人 日本油化学会

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