Dietary Supplementation of Gamma-Linolenic Acid Improves Skin Parameters in Subjects with Dry Skin and Mild Atopic Dermatitis
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- Kawamura Asuka
- Idemitsu Technofine Co.,Ltd.
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- Ooyama Katsuhiko
- Central Research Laboratory, The Nisshin OilliO Group, Ltd.
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- Kojima Keiichi
- Central Research Laboratory, The Nisshin OilliO Group, Ltd.
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- Kachi Hisanori
- Central Research Laboratory, The Nisshin OilliO Group, Ltd.
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- Abe Tatsuichirou
- Central Research Laboratory, The Nisshin OilliO Group, Ltd.
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- Amano Kazutoshi
- Idemitsu Technofine Co.,Ltd.
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- Aoyama Toshiaki
- Central Research Laboratory, The Nisshin OilliO Group, Ltd.
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抄録
Disruption of the skin barrier function caused by epidermal hyper-proliferation, results in the skin becoming dry and showing high transepidermal water loss (TEWL). Gamma linolenic acid (GLA) is reportedly efficacious for treating TEWL and epidermal hyper-proliferation. In this study, to elucidate the effect of GLA-rich oil on skin function, GLA-containing food was given to adults with dry skin or mild atopic dermatitis and skin parameters were evaluated. In the results, we recognized beneficial effects on the TEWL index. The efficacy of GLA was also demonstrated to be statistically significant especially in subjects with pro-inflammatory features. The results suggest that the mechanism of improvement of skin barrier has been associated with possible generation of anti-inflammatory metabolites from GLA. The clinical physician also confirmed that none of the subjects showed any noteworthy side effects. GLA-enriched food appears to be safe and to improve skin barrier function in subjects with dry skin conditions and mild atopic dermatitis.
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 60 (12), 597-607, 2011
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204093142656
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- NII論文ID
- 130001373811
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 023305373
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可