Safety of Dietary Conjugated Linoleic Acid (CLA) in a 12-weeks Trial in Healthy Overweight Japanese Male Volunteers
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- Iwata Toshio
- Research Laboratory, The Nisshin OilliO Group, Ltd.
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- Kamegai Takeshi
- Research Laboratory, The Nisshin OilliO Group, Ltd.
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- Yamauchi-Sato Yoshie
- Research Laboratory, The Nisshin OilliO Group, Ltd.
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- Ogawa Akiko
- Research Laboratory, The Nisshin OilliO Group, Ltd.
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- Kasai Michio
- Research Laboratory, The Nisshin OilliO Group, Ltd.
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- Aoyama Toshiaki
- Research Laboratory, The Nisshin OilliO Group, Ltd.
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- Kondo Kazuo
- Institute of Environmental Science for Human Life, Ochanomizu University
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A study was conducted to investigate the short-term safety of dietary conjugated linoleic acid (CLA) in overweight Japanese male volunteers. The study design was a randomized, double-blind placebo-controlled trial including 60 healthy overweight volunteers (body mass index (BMI), 25~35 kg/m2). The subjects were randomly assigned to three groups: 5.4 g CLA-triacylglycerol (3.4 g as CLA), 10.8 g CLA-triacylglycerol (6.8 g as CLA) and placebo (10.8 g safflower oil) daily for 12 weeks. The CLA-triaclyglycerol contained 9c,11t- and 10t,12c-isomers at an equal proportion. The safety was evaluated by analyses of blood parameters and by clinical examinations at the baseline, and at 6 and 12 weeks, including vital signs and adverse effects. All subjects completed the study. The occurrence of adverse events tended to be higher in the CLA groups than in the placebo group, but all of the adverse events were mild to moderate, within normal ranges, and temporary. Serum aspartate aminotransferase (AST) activity did not differ significantly between the groups at 12 weeks, but in the high CLA group it was slightly increased from the baseline. Serum alanine aminotransferase (ALT) activity was higher in the high CLA group than in the placebo group after 12 weeks and was higher than at the baseline in both CLA groups. However, statistical analysis of the population of apparently healthy volunteers who had normal blood parameters at the baseline revealed that AST and ALT levels did not differ significantly among the 3 groups at 12 weeks. Moreover, no clinically significant changes in vital signs were observed in any of the groups. These results indicate that CLA at a dose of 3.4 g/day is a safe dietary level in healthy Japanese populations in terms of the parameters examined.<br>
収録刊行物
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- Journal of Oleo Science
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Journal of Oleo Science 56 (10), 517-525, 2007
公益社団法人 日本油化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204093462528
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- NII論文ID
- 130000055524
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- NII書誌ID
- AA11503337
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- ISSN
- 13473352
- 13458957
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- NDL書誌ID
- 8909209
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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