Palmitoleic Acid Calcium Salt: A Lubricant and Bactericidal Powder from Natural Lipids

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  • Yamamoto Yoshiaki
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
  • Kawamura Yuki
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
  • Yamazaki Yuki
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
  • Kijima Tatsuro
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University
  • Morikawa Toshiya
    Skin-beauty Laboratories, Kao Corporation
  • Nonomura Yoshimune
    Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University

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Palmitoleic acid is a promising bactericidal agent for cleansing products with alternative bactericidal abilities. In this study, we focus on the physical and biological activity of palmitoleic acid calcium salt (C16:1 fatty acid Ca salt) because it forms via an ion-exchange reaction between palmitoleic acid and Ca ions in tap water, and remains on the skin surface during the cleansing process. Here, we prepared C16:1 fatty acid Ca salt to investigate its crystal structure and physical and bactericidal properties. The Ca salt was a plate-shaped lamellar crystalline powder with a particle diameter of several micrometers to several tens of micrometers; it exhibited significant lubricity and alternative bactericidal activity against Staphylococcus aureus (S. aureus) and Propionibacterium acnes (P. acnes). We also examined other fatty acid Ca salts prepared from lauric acid (C12:0 fatty acid), palmitic acid (C16:0 fatty acid), and oleic acid (C18:1 fatty acid). The bactericidal activities and lubricity of the fatty acid Ca salts changed with the alkyl chain length and the degree of unsaturation. The C16:1 fatty acid Ca salt exhibited the strongest selective bactericidal ability among the four investigated fatty acid Ca salts. These findings suggest that C16:1 fatty acid and its Ca salt have potential applications in cleansing and cosmetic products.

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