Cytotoxicity of Photosensitizing Crystalline C₆₀ Particles Formed by Ink-jet Method

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  • BAN Masahito
    Nippon Institute of Technology Innovative Systems Engineering
  • KOGI Yuuya
    Nippon Institute of Technology Innovative Systems Engineering
  • SASAKI Fusako
    Nippon Institute of Technology Innovative Systems Engineering

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タイトル別名
  • Cytotoxicity of Photosensitizing Crystalline C<sub>60</sub> Particles Formed by Ink-jet Method

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抄録

The crystalline C60 particles were synthesized into PDMS-based microwells on microarray chips using an ink-jet spotting system, and the effect of the particles on cytotoxicity was investigated using HeLa cells (human cervical carcinoma cell). It was found from SEM observations that a number of C60 particles were formed along the edges of 300μm microwells, which could have enough area to encapsulate several tens of cells in the center. The tests with HeLa cells revealed that the C60 particles irradiated green laser caused cytotoxicity, and the rate of cell death was controlled by the irradiation time. It was suggested that the cytotoxicity was induced by reactive oxygen species (ROS) generated by the C60 particles, and an effect of the ROS on the cells covered a large part of the microwell.

収録刊行物

  • 日本画像学会誌

    日本画像学会誌 51 (5), 496-500, 2012

    一般社団法人 日本画像学会

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