The Effect of Serum Albumin Levels on Circadian Rhythm of Blood Pressure in Patients with Chronic Kidney Disease

DOI
  • Andoh Daisaku
    Division of Nephrology, Yokohama City University School of Medicine
  • Yasuda Gen
    Division of Nephrology, Yokohama City University School of Medicine
  • Kobayashi Mayumi
    Division of Nephrology, Yokohama City University School of Medicine
  • Kaneda Tomoko
    Division of Nephrology, Yokohama City University School of Medicine
  • Yoshida Tugumi
    Division of Nephrology, Yokohama City University School of Medicine
  • Kobayasi Tinatu
    Division of Nephrology, Yokohama City University School of Medicine
  • Saka Sanae
    Division of Nephrology, Yokohama City University School of Medicine
  • Yatsu Keisuke
    Division of Nephrology, Yokohama City University School of Medicine
  • Hirawa Nobuhito
    Division of Nephrology, Yokohama City University School of Medicine
  • Umemura Satoshi
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine

Bibliographic Information

Other Title
  • 慢性腎臓病(Chronic Kidney Disease: CKD)における血清アルブミン値の血圧日内変動への影響

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Description

Background: In chronic kidney disease(CKD), renal dysfunction is associated with a loss of nocturnal blood pressure(BP) reduction. However, it remains unclear about the circadian rhythm of BP in CKD with hypoalbuminemia resulting from urinary protein excretion. We evaluated the relationship between the circadian BP rhythm and serum albumin level(S-Alb).<BR>Methods: Non-diabetic CKD patients without progressive renal dysfunction(serum creatinine level<1.5mg/dl) were divided into two groups, based on S-Alb: nephrotic syndrome(NS) group(less than 3.0g/dl; n=30) and Hypoalbuminemia group(3.0 to 4.0g/dl; n=32). Age and sex-matched normal subjects with normal albumin level(more than 4.0g/dl; n=32) were enrolled as Control group. Ambulatory 24-hour BP monitoring was conducted in all subjects.<BR>Results: There were no significant differences in 24-hour BP among three groups. However, sleeping/waking mean BP ratios were significantly increased gradually in the Control, Hypoalbuminemia and NS groups, in that order(0.85±0.07, 0.91±0.08, 0.96±0.08, respectively; p<0.05 for respective two groups). A significant reverse correlation was observed between S-Alb and sleeping/waking ratio of mean BP(r=−0.58; p<0.001).<BR>Conclusion: In non-diabetic CKD patients, loss of nocturnal BP reduction occurred even in the early stage, correlating with S-Alb.

Journal

  • CIRCULATION CONTROL

    CIRCULATION CONTROL 30 (1), 8-18, 2009

    Japan Society of Circulation Control in Medicine

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