Evaluation of the Estrogenic Activity for Mixture of Chemicals and Environmental Samples by the Estrogen Receptor Binding Assay

DOI

Bibliographic Information

Other Title
  • 受容体結合試験による複合試料のエストロゲン活性の評価

Search this article

Description

A wide range of chemicals are reported to have a hormonal activity. These chemicals are classified with two groups; agonist and antagonist. When we measure hormonal activity in samples which contains both agonist and antagonist such as environmental water, it's difficult to obtain the total concentrations of chemicals binding to estrogen receptor. In this paper, we tried to measure the estrogenic activity by estrogen receptor binding assay. We arranged some mixtures of single/multi-component chemicals, and applied their relationships between concentrations and inhibition ratios with sigmoidal formulas. The results of estrogen receptor binding assay gave us the total concentrations of chemicals binding to estrogen receptor even if samples contained with both agonist and antagonist. The total concentrations of these chemicals were expressed with the equivalent values of 17β-estradiol.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390001204111877120
  • NII Article ID
    130003775786
  • DOI
    10.11532/proes1992.40.617
  • ISSN
    1884829X
    13415115
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top