A Practical Synthesis of Optically Active (<i>R</i>)-2-Propyloctanoic Acid: Therapeutic Agent for Alzheimer's Disease
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- Hasegawa Tomoyuki
- Graduate School of Engineering, Nagoya University
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- Yamamoto Hisashi
- Graduate School of Engineering, Nagoya University
書誌事項
- タイトル別名
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- A Practical Synthesis of Optically Active (R)-2-Propyloctanoic Acid: Therapeutic Agent for Alzheimer's Disease.
- Practical Synthesis of Optically Active R 2 Propyloctanoic Acid Therapeutic Agent for Alzheimer s Disease
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(R)-2-Propyloctanoic acid has been developed as a novel therapeutic agent for Alzheimer's disease. A large-scale synthesis of this candidate was achieved by using Oppolzer's camphorsultam as a chiral auxiliary under improved conditions. It was essential for the successful synthesis of this compound to utilize a new removal method for the chiral source with a combination of tetrabutylammonium hydroxide and hydrogen peroxide. The present process afforded the desired product in high yield with high optical purity.
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 73 (2), 423-428, 2000
公益社団法人 日本化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204121668736
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- NII論文ID
- 130004150586
- 10009144460
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- NII書誌ID
- AA00580132
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- COI
- 1:CAS:528:DC%2BD3cXpsVSntA%3D%3D
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- ISSN
- 13480634
- 00092673
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- NDL書誌ID
- 4988001
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可