A Synthesis of (+)-Cyclaradine, Carbocyclic Analogue of 9-β-<scp>d</scp>-Arabinofuranosyladenine

DOI DOI PDF 被引用文献2件 参考文献14件 オープンアクセス
  • Tadano Kin-ichi
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University
  • Kimura Hiroshi
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University
  • Ogawa Seiichiro
    Department of Applied Chemistry, Faculty of Science and Technology, Keio University

書誌事項

タイトル別名
  • A synthesis of (+)-cyclaradine, carbocyclic analogue of 9-.BETA.-D-arabinofuranosyladenine.
  • ChemInform Abstract: A Synthesis of (+)‐Cyclaradine, Carbocyclic Analogue of 9‐β‐D‐Arabinofuranosyladenine.

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説明

The title compound, a promising antiviral carbocyclic nucleoside analogue, was synthesized enantiospecifically. The present synthesis involves a coupling reaction of 5-amino-4,6-dichloropyrimidine and (1R,2R,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentanamine which was in turn prepared from D-xylose.

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