The Synthesis of 2,3-Dimethoxy-5-methyl-<I>p</I>-benzoquinone
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- Sato Kikumasa
- Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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- Inoue Seiichi
- Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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- Sato Haruhito
- Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
Description
2,3-Dimethoxy-5-methylbenzoquinone, the key intermediate of the synthesis of coenzyme Q, was synthesized via two new routes. The methylation of 5-nitrovanillin gave 5-nitroveratraldehyde, which was then catalytically reduced to afford 5-aminohomoveratrol. The oxidation of 5-aminohomoveratrol gave 2,3-dimethoxy-5-methylbenzoquinone. 2,3,4-Trimethoxyphenol was obtained by the decarboxylation of 3,4,5-trimethoxysalicylic acid. This was converted via Mannich reaction to 2,3,4-trimethoxy-6-methylphenol, which was then easily oxidized to 2,3-dimethoxy-5-methylbenzoquinone.
Journal
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 45 (11), 3455-3457, 1972
The Chemical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204137053824
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- NII Article ID
- 130001975681
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- ISSN
- 13480634
- 00092673
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed