A Bioorganic Chemistry Approach to Understanding Molecular Recognition in Protein–Nucleic Acid Complexes
-
- Morii Takashi
- Institute of Advanced Energy, Kyoto University
Bibliographic Information
- Other Title
-
- Award Account : The Chemical Society of Japan Award for Creative Work for 2016 : A Bioorganic Chemistry Approach to Understanding Molecular Recognition in Protein-Nucleic Acid Complexes
Search this article
Abstract
<p>A combination of synthetic, organic, and biochemical approaches has been developed to study how protein and nucleic acid assemblies modulate the affinity, specificity and cooperativity of protein–nucleic acid interactions. These strategies have enabled formation of noncovalent peptide dimers on specific DNA sequences. A new framework from RNA and peptide into a stable complex of ribonucleopeptide was also developed to construct receptors and fluorescent sensors for small molecules. Attempts to design novel DNA-binding peptides, receptors and sensors will provide an ultimate test for our understanding of the principle of molecular recognition associated with protein–nucleic acid interactions.</p>
Journal
-
- Bulletin of the Chemical Society of Japan
-
Bulletin of the Chemical Society of Japan 90 (12), 1309-1317, 2017
The Chemical Society of Japan
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001204144371712
-
- NII Article ID
- 130006250397
-
- NII Book ID
- AA00580132
-
- ISSN
- 13480634
- 00092673
-
- NDL BIB ID
- 028707585
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed