Unique sex determination system in the silkworm, Bombyx mori : current status and beyond
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- KATSUMA Susumu
- Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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- KIUCHI Takashi
- Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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- KAWAMOTO Munetaka
- Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
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- FUJIMOTO Toshiaki
- Laboratory of Applied Entomology, Faculty of Agriculture, Iwate University
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- SAHARA Ken
- Laboratory of Applied Entomology, Faculty of Agriculture, Iwate University
書誌事項
- タイトル別名
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- Unique sex determination system in the silkworm, <i>Bombyx mori</i>: current status and beyond
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説明
<p>The silkworm Bombyx mori has been used for silk production for over 5,000 years. In addition to its contribution to sericulture, B. mori has played an important role in the field of genetics. Classical genetic studies revealed that a gene(s) with a strong feminizing activity is located on the W chromosome, but this W-linked feminizing gene, called Feminizer (Fem), had not been cloned despite more than 80 years of study. In 2014, we discovered that Fem is a precursor of a single W chromosome-derived PIWI-interacting RNA (piRNA). Fem-derived piRNA binds to PIWI protein, and this complex then cleaves the mRNA of the Z-linked Masculinizer (Masc) gene, which encodes a protein required for both masculinization and dosage compensation. These findings showed that the piRNA-mediated interaction between the two sex chromosomes is the primary signal for the sex determination cascade in B. mori. In this review, we summarize the history, current status, and perspective of studies on sex determination and related topics in B. mori.</p>
収録刊行物
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- Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｊａｐａｎ Ａｃａｄｅｍｙ． Ｓｅｒ． Ｂ： Ｐｈｙｓｉｃａｌ ａｎｄ Ｂｉｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ
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Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｊａｐａｎ Ａｃａｄｅｍｙ． Ｓｅｒ． Ｂ： Ｐｈｙｓｉｃａｌ ａｎｄ Ｂｉｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ 94 (5), 205-216, 2018-05-11
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詳細情報 詳細情報について
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- CRID
- 1390001204145027456
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- NII論文ID
- 130006733759
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- NII書誌ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- NDL書誌ID
- 028994769
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- PubMed
- 29760316
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- 本文言語コード
- en
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- 資料種別
- journal article
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- NDLサーチ
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- PubMed
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