A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.
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- OSADA HIROYUKI
- RIKEN, The Institute of Physical and Chemical Research
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- KOSHINO HIROYUKI
- RIKEN, The Institute of Physical and Chemical Research
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- KUDO TAKUJI
- RIKEN, The Institute of Physical and Chemical Research
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- ONOSE RIE
- RIKEN, The Institute of Physical and Chemical Research
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- ISONO KIYOSHI
- RIKEN, The Institute of Physical and Chemical Research
書誌事項
- タイトル別名
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- I. TAXONOMY AND BIOLOGICAL ACTIVITY
- 公開日
- 1992
- 資源種別
- journal article
- DOI
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- 10.7164/antibiotics.45.189
- 公開者
- 公益財団法人 日本感染症医薬品協会
この論文をさがす
説明
A novel inhibitor of protein kinase C was found in the fermentation of a soil actinomycete, strain RK-1409. According to the taxonomic studies, the producing strain was designated as Streptomyces platensis subsp. malvinus RK-1409. The protein kinase C inhibitor, RK-1409 (7-oxostaurosporine) inhibited the morphological change of a human chronic erythroleukemia cell, K-562, induced by phorbol 12, 13-dibutyrate (PDBu) at the concentration of 10ng/ml. The concentration of 3ng/ml inhibited the activity of protein kinase C in vitro. RK-1409 inhibited the cell cycle progression at G2 phase of K-562 cells.
収録刊行物
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- The Journal of Antibiotics
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The Journal of Antibiotics 45 (2), 189-194, 1992
公益財団法人 日本感染症医薬品協会
