The biological significance of ω-oxidation of fatty acids
-
- MIURA Yoshiro
- Teikyo University
Search this article
Abstract
The author focuses on the biological significance of ω-oxidation of fatty acids. Early studies revealed that there is a subsidiary pathway for β-oxidation of fatty acids when β-oxidation is blocked. Many studies demonstrated that the ω-oxidation serves to provide succinyl-CoA for the citric acid cycle and for gluconeogenesis under conditions of starvation and diabetes. Acylglucosylceramides which are composed of linoleic acid, long chain ω-hydroxy fatty acids, eicosasphingenine (or trihydroxyeicosasphingenine) and glucose, are responsible for normal epidermal permeability function in the skin. It is observed that ω- and (ω-1)-oxidation of fatty acids are related to energy metabolism in some laboratory animals such as musk shrews and Mongolian gerbils. Studies confirmed that ω- and (ω-1)-oxidation of fatty acids play crucial roles in the production of insect pheromones of honeybees and in the formation of biopolyesters of higher plants. In addition, the biological significance of ω-oxidation of prostaglandins and leukotrienes is described.<BR><BR>(Communicated by Tamio Yamakawa, M.J.A.)
Journal
-
- Proceedings of the Japan Academy, Series B
-
Proceedings of the Japan Academy, Series B 89 (8), 370-382, 2013
The Japan Academy
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001204146441344
-
- NII Article ID
- 130004802292
-
- NII Book ID
- AA00785485
-
- COI
- 1:STN:280:DC%2BC2c%2FntVSgug%3D%3D
-
- ISSN
- 13492896
- 03862208
-
- NDL BIB ID
- 025080457
-
- PubMed
- 24126285
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed